The Hazards of Gadolinium: Gadolinium-based contrast agents can be hazardous to patients who have multiple scans, because deposits of contrast agent can accumulate in their brains. Nephrogenic systemic fibrosis, which is fibrosis of the skin, joints, eyes, or internal organs. can develop. In severe cases patients cannot walk or fully extend their arms, feet, and legs, and they may experience muscle weakness. The condition has a 48% death rate.